靶标：
CHRNB3
产品别名：
CHRNB3； cholinergic receptor nicotinic beta 3 subunit； cholinergic receptor nicotinic beta 3 subunit； neuronal acetylcholine receptor subunit beta-3； acetylcholine receptor, neuronal nicotinic, beta-3 subunit； acetylcholine receptor, nicotinic, beta 3 (neuronal)； cholinergic receptor, nicotinic beta 3； cholinergic receptor, nicotinic, beta 3 (neuronal)； cholinergic receptor, nicotinic, beta polypeptide 3； 烟碱型乙酰胆碱受体β3； 烟碱型胆碱受体β3(CHRNb3)；
背景信息：
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N
