靶标:
CLCN4
产品别名:
CLC4; ClC-4; ClC-4A; MRX15; MRX49; MRXSRC; CLCN4; chloride voltage-gated channel 4; chloride voltage-gated channel 4; H(+)/Cl(-) exchange transporter 4; chloride channel 4; chloride channel protein 4; chloride channel, voltage-sensitive 4; chloride transporter ClC-4;
背景信息:
chloride voltage-gated channel 4(CLCN4) Homo sapiens The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012],