靶标：
CCR1
产品别名：
CD191； CKR-1； CKR1； CMKBR1； HM145； MIP1aR； SCYAR1； CCR1； C-C motif chemokine receptor 1； C-C motif chemokine receptor 1； C-C chemokine receptor type 1； C-C CKR-1； CC-CKR-1； CCR-1； LD78 receptor； MIP-1alpha-R； RANTES receptor； RANTES-R； chemokine (C-C motif) receptor 1； macrophage inflammatory protein 1-alpha receptor； 细胞表面趋化因子受体1； 趋化因子C-C-基元受体1(CCR1)；
背景信息：
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]
