靶标:
CREM
产品别名:
CREM-2; ICER; hCREM-2; CREM; cAMP responsive element modulator; cAMP responsive element modulator; cAMP-responsive element modulator; CREM 2alpha-b protein; CREM 2beta-a protein; cAMP response element modulator; inducible cAMP early repressor ICER; 环磷酸腺苷反应元件调节蛋白;
背景信息:
cAMP responsive element modulator(CREM) Homo sapiens This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008],