靶标:
CRHR2
产品别名:
CRF-RB; CRF2; CRFR2; HM-CRF; CRHR2; corticotropin releasing hormone receptor 2; corticotropin releasing hormone receptor 2; corticotropin-releasing factor receptor 2; CRH-R2; 促肾上腺皮质素释放激素受体2(CRHR2); 促肾上腺皮质释放激素受体2;
背景信息:
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011],