靶标:
CRY1
产品别名:
DSPD; PHLL1; CRY1; cryptochrome circadian regulator 1; cryptochrome circadian regulator 1; cryptochrome-1; cryptochrome 1 (photolyase-like); cryptochrome circadian clock 1; 隐色素1(CRY1); 隐花色素蛋白1;
背景信息:
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014],