靶标:
CSNK2A2
产品别名:
CK2A2; CK2alpha'; CSNK2A1; CSNK2A2; casein kinase 2 alpha 2; casein kinase 2 alpha 2; casein kinase II subunit alpha'; CK II alpha'; casein kinase 2 alpha'; casein kinase 2, alpha prime polypeptide;
背景信息:
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Tetramer composed of an alpha chain, an alpha' and two beta chains. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation.,