靶标：
CYBB
产品别名：
AMCBX2； CGD； CGDX； GP91-1； GP91-PHOX； GP91PHOX； IMD34； NOX2； p91-PHOX； CYBB； cytochrome b-245 beta chain； cytochrome b-245 beta chain； cytochrome b-245 heavy chain； CGD91-phox； NADPH oxidase 2； cytochrome b(558) subunit beta； cytochrome b-245 beta polypeptide； cytochrome b558 subunit beta； heme-binding membrane glycoprotein gp91phox； neutrophil cytochrome b 91 kDa polypeptide； p22 phagocyte B-cytochrome； superoxide-generating NADPH oxidase heavy chain subunit； NADPH氧化酶2； 细胞色素b-245β肽(CYBb)；
背景信息：
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008],
