靶标:
CYP26A1
产品别名:
CP26; CYP26; P450RAI; P450RAI1; CYP26A1; cytochrome P450 family 26 subfamily A member 1; cytochrome P450 family 26 subfamily A member 1; cytochrome P450 26A1; P450, retinoic acid-inactivating, 1; cytochrome P450 retinoic acid-inactivating 1; cytochrome P450, family 26, subfamily A, polypeptide 1; cytochrome P450, subfamily XXVIA, polypeptide 1; cytochrome P450RAI; hP450RAI; retinoic acid 4-hydroxylase; retinoic acid-metabolizing cytochrome; 细胞色素cP450 CYP26A1; 细胞色素P450家族成员26A1(CYP26A1);
背景信息:
cytochrome P450 family 26 subfamily A member 1(CYP26A1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008],