靶标：
DCC
产品别名：
CRC18； CRCR1； HGPPS2； IGDCC1； MRMV1； NTN1R1； DCC； DCC netrin 1 receptor； DCC netrin 1 receptor； netrin receptor DCC； colorectal cancer suppressor； deleted in colorectal carcinoma； immunoglobulin superfamily DCC subclass member 1； putative colorectal tumor suppressor； tumor suppressor protein DCC； 结肠直肠癌缺失基因；
背景信息：
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009],
