靶标:
DCK
产品别名:
DCK; deoxycytidine kinase; deoxycytidine kinase; deoxycytidine kinase; deoxyadenosine kinase; deoxyguanosine kinase; deoxynucleoside kinase; 脱氧胞苷激酶; 脱氧胞苷激酶(DCK);
背景信息:
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008],