靶标：
DGUOK
产品别名：
MTDPS3； NCPH； NCPH1； PEOB4； dGK； DGUOK； deoxyguanosine kinase； deoxyguanosine kinase； deoxyguanosine kinase, mitochondrial； deoxyadenosine kinase, mitochondrial； 脱氧鸟苷激酶；
背景信息：
In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene.
