靶标：
DIO2
产品别名：
5DII； D2； DIOII； SELENOY； SelY； TXDI2； DIO2； iodothyronine deiodinase 2； iodothyronine deiodinase 2； type II iodothyronine deiodinase； deiodinase, iodothyronine type II； deiodinase-2； deiodonase-2； selenoprotein Y； thyroxine deiodinase, type II； type 2 DI； type 2 iodothyronine deiodinase； type-II 5'-deiodinase； type-II 5'deiodinase； 碘甲腺原氨酸脱碘酶Ⅱ(DIO2)； 脱碘酶2；
背景信息：
deiodinase, iodothyronine type II(DIO2) Homo sapiens The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is widely expressed, including in thyroid, placenta, pituitary and brain. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tissues. It has also been reported to be highly expressed in thyroids of patients with Graves disease, and in follicular adenomas. The intrathyroidal T4 to T3 conversion by this enzyme may contribute significantly to the relative increase in thyroidal T3 production in these patients. This protein is a selenoprotein containing the rare selenocysteine (Sec) amino acid at its active site, and may
