靶标：
DIO3
产品别名：
5DIII； D3； DIOIII； TXDI3； DIO3； iodothyronine deiodinase 3； iodothyronine deiodinase 3； thyroxine 5-deiodinase； deiodinase, iodothyronine type III； iodothyronine deiodinase, placental type； selenoprotein DIO3； thyroxine deiodinase type III (selenoprotein)； type 3 DI； type 3 iodothyronine selenodeiodinase； type-III 5' deiodinase； 甲状腺素5'脱碘酶3； 碘甲腺原氨酸脱碘酶Ⅲ(DIO3)；
背景信息：
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in pregnant uterus, placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It regulates circulating fetal thyroid hormone concentrations, and thus plays a critical role in mammalian development. Knockout mice lacking this gene exhibit abnormalities related to development and reproduction, and increased activity of this enzyme in infants with hemangiomas causes severe hypothyroidism. This protei
