靶标:
DNASE1L3
产品别名:
DHP2; DNAS1L3; LSD; SLEB16; DNASE1L3; deoxyribonuclease 1 like 3; deoxyribonuclease 1 like 3; deoxyribonuclease gamma; DNase I homolog protein 2; DNase I homolog protein DHP2; DNase I-like 3; DNase gamma; LS-DNase; Liver and spleen DNase; deoxyribonuclease I-like 3; deoxyribonuclease I-like III; DNA酶Ⅰ样蛋白3(DNASE1L3); 脱氧核糖核酸酶γ;
背景信息:
This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.