靶标:
DPP6
产品别名:
DPL1; DPPX; MRD33; VF2; DPP6; dipeptidyl peptidase like 6; dipeptidyl peptidase like 6; dipeptidyl aminopeptidase-like protein 6; DPP VI; dipeptidyl aminopeptidase IV-related protein; dipeptidyl peptidase IV-related protein; dipeptidyl peptidase VI; dipeptidyl-peptidase 6; 二肽基肽酶6; 二肽基肽酶6(DPP6);
背景信息:
This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014],