靶标:
DRD4
产品别名:
D4DR; DRD4; dopamine receptor D4; dopamine receptor D4; D(4) dopamine receptor; D(2C) dopamine receptor; dopamine D4 receptor; seven transmembrane helix receptor; 多巴胺受体D4; 多巴胺受体D4(DRD4);
背景信息:
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008],