靶标：
ERCC6
产品别名：
ARMD5； CKN2； COFS； COFS1； CSB； CSB-PGBD3； POF11； RAD26； UVSS1； ERCC6； ERCC excision repair 6, chromatin remodeling factor； ERCC excision repair 6, chromatin remodeling factor； DNA excision repair protein ERCC-6； ERCC6-PGBD3 fusion protein； ATP-dependent helicase ERCC6； Chimeric CSB-PGBD3 protein； Chimeric ERCC6-PGBD3 protein； Cockayne syndrome group B protein； cockayne syndrome protein CSB； excision repair cross-complementation group 6； excision repair cross-complementing rodent repair deficiency, complementation group 6； ATP依赖解旋酶ERCC6；
背景信息：
This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3' splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3 (GeneID:267004), which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene. [provided by RefSeq, Mar 2016],
