靶标：
ETFA
产品别名：
EMA； GA2； MADD； ETFA； electron transfer flavoprotein subunit alpha； electron transfer flavoprotein subunit alpha； electron transfer flavoprotein subunit alpha, mitochondrial； alpha-ETF； electron transfer flavoprotein alpha subunit； electron transfer flavoprotein, alpha polypeptide； epididymis secretory sperm binding protein； glutaric aciduria II； 电子转移黄素蛋白α； 电子转移黄素蛋白α肽(ETFa)；
背景信息：
The human ETFA gene encodes the Electron-transfer-flavoprotein, alpha subunit, also known as ETF-α. Together with Electron-transfer-flavoprotein, beta subunit, encoded by the 'ETFB' gene, it forms the heterodimericElectron transfer flavoprotein (ETF). ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene.
