靶标:
EYA3
产品别名:
EYA3; EYA transcriptional coactivator and phosphatase 3; EYA transcriptional coactivator and phosphatase 3; eyes absent homolog 3; eyes absent 3; EYA3蛋白;
背景信息:
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. It can act as a mediator of chemoresistance and cell survival in Ewing sarcoma cells, where this gene is up-regulated via a micro-RNA that binds to the 3' UTR of the transcript. A similar protein in mice acts as a transcriptional activator. Alternative splicing of this gene results in multiple transcript variants.