靶标:
ACSL1
产品别名:
ACS1; FACL1; FACL2; LACS; LACS1; LACS2; ACSL1; acyl-CoA synthetase long chain family member 1; acyl-CoA synthetase long chain family member 1; long-chain-fatty-acid--CoA ligase 1; LACS 1; LACS 2; acyl-CoA synthetase 1; arachidonate--CoA ligase; fatty-acid-Coenzyme A ligase, long-chain 1; fatty-acid-Coenzyme A ligase, long-chain 2; lignoceroyl-CoA synthase; long-chain acyl-CoA synthetase 1; long-chain acyl-CoA synthetase 2; long-chain fatty acid-CoA ligase 2; long-chain fatty-acid-coenzyme A ligase 1; palmitoyl-CoA ligase 1; palmitoyl-CoA ligase 2; paltimoyl-CoA ligase 1; phytanate--CoA ligase; 酰基辅酶A合成酶长链家族成员1(ACSL1); 长链脂肪酸辅酶A连接酶1/2;
背景信息:
哺乳动物长链酰基辅酶A合成酶 (ACSL) 可催化脂肪酸与 CoA 的连接,从而在两步反应中形成脂肪酰辅酶A (1)。已识别五种 ACSL 同工型 (1)。这些同工型具有不同的底物偏好和亚细胞定位 (1)。ACSL1 的过表达导致大鼠原代干细胞中的脂肪酸代谢发生改变 (2)。