靶标：
FMO3
产品别名：
FMOII； TMAU； dJ127D3.1； FMO3； flavin containing dimethylaniline monoxygenase 3； flavin containing dimethylaniline monoxygenase 3； dimethylaniline monooxygenase [N-oxide-forming] 3； FMO form 2； dimethylaniline oxidase 3； flavin containing monooxygenase 3； hepatic flavin-containing monooxygenase-3； trimethylamine monooxygenase； 二甲基苯胺单加氧酶3； 含黄素单加氧酶3(FMO3)；
背景信息：
flavin containing monooxygenase 3(FMO3) Homo sapiens Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gen
