靶标:
MSTN
产品别名:
GDF8; MSLHP; MSTN; myostatin; myostatin; growth/differentiation factor 8; myostatin-b; 生长分化因子8; 生长分化因子8/肌肉抑制素; 生长分化因子8/肌肉抑制素封闭多肽; 肌肉生长抑制素(MSTN);
背景信息:
myostatin(MSTN) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016],