靶标：
GLA
产品别名：
GALA； GLA； galactosidase alpha； galactosidase alpha； alpha-galactosidase A； agalsidase alfa； alpha-D-galactosidase A； alpha-D-galactoside galactohydrolase 1； alpha-gal A； galactosylgalactosylglucosylceramidase GLA； melibiase； α-半乳糖苷酶； 半乳糖苷酶α(GLa)；
背景信息：
Alpha-galactosidase is a glycoside hydrolase enzyme that encoded by the GLA gene. This gene is a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.
