靶标:
GRIN2C
产品别名:
GluN2C; NMDAR2C; NR2C; GRIN2C; glutamate ionotropic receptor NMDA type subunit 2C; glutamate ionotropic receptor NMDA type subunit 2C; glutamate receptor ionotropic, NMDA 2C; GluN2C(alt_5'UTR_77nt); GluN2C(alt_5'UTR_87nt); GluN2C(del_e2); GluN2C-b alternative isoform; N-methyl D-aspartate receptor subtype 2C; N-methyl-D-aspartate receptor subunit 2C; glutamate [NMDA] receptor subunit epsilon-3; glutamate receptor, ionotropic, N-methyl D-aspartate 2C; putative NMDtranscript(altAcc_e11); putative NMDtranscript(altDon_e4); putative NMDtranscript(del_e4); N-甲基-D-天氡氨酸离子能谷氨酸受体2C(GRIN2C); 谷氨酸受体2C; 谷氨酸受体2C(N端);
背景信息:
This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013],