靶标：
HLA-DQA1
产品别名：
CELIAC1； DQ-A1； DQA1； HLA-DQA； HLA-DQB1； HLA-DQA1； major histocompatibility complex, class II, DQ alpha 1； major histocompatibility complex, class II, DQ alpha 1； HLA class II histocompatibility antigen, DQ alpha 1 chain； DC-1 alpha chain； DC-alpha； HLA class II histocompatibility antigen DQ alpha chain； HLA-DCA； MHC HLA-DQ alpha； MHC class II DQ alpha chain； MHC class II DQA1； MHC class II HLA-DQ-alpha-1； MHC class II antigen DQA1； MHC class II protein； 组织相容性抗原DQA1； 组织相容性抗原DQA1/DQA2； 组织相容性抗原DQA2；
背景信息：
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marro
