靶标:
HSPA4
产品别名:
APG-2; HEL-S-5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY; HSPA4; heat shock protein family A (Hsp70) member 4; heat shock protein family A (Hsp70) member 4; heat shock 70 kDa protein 4; epididymis secretory sperm binding protein Li 5a; heat shock 70-related protein APG-2; heat shock 70kD protein 4; heat shock protein, 110 kDa; hsp70 RY; 70kDa热休克蛋白4(HSPA4); 热休克蛋白70蛋白4;
背景信息:
热休克蛋白 HSPA4 (Apg-2, HSP70RY) 是 Hsp70 热休克蛋白的热休克蛋白 110 (Hsp 110) 亚家族成员之一 (1)。Apg-2 具有与 Hsp110 相似的分子伴侣能力,其在非应激条件下发挥作用 (2)。Apg-2 与 TJP1/ZO-1 相互作用,并可作为上皮细胞中 ZO-1-ZONAB 信号转导的调节分子发挥作用,对细胞应激作出应答 (3,4)。