靶标：
HTR2C
产品别名：
5-HT1C； 5-HT2C； 5-HTR2C； 5HTR2C； HTR1C； HTR2C； 5-hydroxytryptamine receptor 2C； 5-hydroxytryptamine receptor 2C； 5-hydroxytryptamine receptor 2C； 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled； 5-hydroxytryptamine receptor 1C； serotonin 5-HT-1C receptor； serotonin 5-HT-2C receptor； 5-羟色胺受体2C； 5-羟色胺受体2C(HTR2C)；
背景信息：
This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015],
