靶标:
IL6ST
产品别名:
CD130; CDW130; GP130; HIES4; HIES4A; HIES4B; IL-6RB; IMD94; STWS2; sGP130; IL6ST; interleukin 6 cytokine family signal transducer; interleukin 6 cytokine family signal transducer; interleukin-6 receptor subunit beta; CD130 antigen; IL-6 receptor subunit beta; IL-6R subunit beta; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130, oncostatin M receptor; interleukin receptor beta chain; interleukin-6 signal transducer; membrane glycoprotein 130; membrane glycoprotein gp130; oncostatin-M receptor subunit alpha; 白细胞介素6受体β/CD130; 糖蛋白130(gp130);
背景信息:
GP130 是细胞因子 IL-6 家族的受体共有的信号转导亚基 (1-3)。配体与其受体的结合诱导 GP130 二聚化,导致 Jak 酪氨酸激酶的激活和 GP130 的酪氨酸磷酸化。这些事件导致其激活受 GP130 的不同区域控制的多条信号转导通路(如 Stat、Ras-MAPK 和 PI3 激酶通路)激活 (4-7)。