靶标：
IL12B
产品别名：
CLMF； CLMF2； IL-12B； IMD28； IMD29； NKSF； NKSF2； IL12B； interleukin 12B； interleukin 12B； interleukin-12 subunit beta； CLMF p40； IL-12 subunit p40； IL12, subunit p40； NK cell stimulatory factor chain 2； cytotoxic lymphocyte maturation factor 40 kDa subunit； interleukin 12, p40； interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)； interleukin-12 beta chain； natural killer cell stimulatory factor, 40 kD subunit； 白介素12B(IL12B)； 白细胞介素12β亚基蛋白； 白细胞介素12p40；
背景信息：
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provi
