靶标：
IL12RB1
产品别名：
CD212； IL-12R-BETA1； IL12RB； IMD30； IL12RB1； interleukin 12 receptor subunit beta 1； interleukin 12 receptor subunit beta 1； interleukin-12 receptor subunit beta-1； IL-12 receptor beta component； IL-12 receptor subunit beta-1； IL-12R subunit beta-1； cluster of differentiation 212； interleukin 12 receptor, beta 1； interleukin-12 receptor beta-1 chain； 白介素12受体β1(IL12Rb1)； 白细胞介素-12受体β1；
背景信息：
interleukin 12 receptor subunit beta 1(IL12RB1) Homo sapiens The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014],
