靶标:
LAMC2
产品别名:
B2T; BM600; CSF; EBR2; EBR2A; JEB3A; JEB3B; LAMB2T; LAMNB2; LAMC2; laminin subunit gamma 2; laminin subunit gamma 2; laminin subunit gamma-2; BM600-100kDa; CSF 140 kDa subunit; cell-scattering factor 140 kDa subunit; epiligrin subunit gamma; kalinin subunit gamma; ladsin 140 kDa subunit; laminin B2t chain; laminin, gamma 2; large adhesive scatter factor 140 kDa subunit; nicein subunit gamma; 层粘连蛋白γ2(LAMC2);
背景信息:
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological func