靶标：
LLGL2
产品别名：
HGL； Hugl-2； LGL2； LLGL2； LLGL scribble cell polarity complex component 2； LLGL scribble cell polarity complex component 2； LLGL scribble cell polarity complex component 2； LLGL2, scribble cell polarity complex component； human giant larvae homolog； lethal giant larvae homolog 2, scribble cell polarity complex component； lethal(2) giant larvae protein homolog 2； 相似肿瘤抑制基因HUGL；
背景信息：
The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms.
