靶标:
LTB
产品别名:
TNFC; TNFSF3; TNLG1C; p33; LTB; lymphotoxin beta; lymphotoxin beta; lymphotoxin-beta; LT-beta; TNF superfamily member 3; TNF-C; lymphotoxin beta (TNF superfamily, member 3); tumor necrosis factor C; tumor necrosis factor ligand 1C; tumor necrosis factor ligand superfamily member 3; 淋巴毒素β(LTb); 肿瘤坏死因子C/淋巴毒素β;
背景信息:
Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],