靶标：
SMAD7
产品别名：
CRCS3； MADH7； MADH8； SMAD7； SMAD family member 7； SMAD family member 7； mothers against decapentaplegic homolog 7； MAD (mothers against decapentaplegic, Drosophila) homolog 7； MAD homolog 8； Mothers against decapentaplegic, drosophila, homolog of, 7； SMAD, mothers against DPP homolog 7； hSMAD7； mothers against DPP homolog 8； Smad同源物7(Smad7)； 细胞信号转导分子SMAD7；
背景信息：
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],
