靶标：
MAP3K4
产品别名：
MAPKKK4； MEKK 4； MEKK4； MTK1； PRO0412； MAP3K4； mitogen-activated protein kinase kinase kinase 4； mitogen-activated protein kinase kinase kinase 4； mitogen-activated protein kinase kinase kinase 4； MAP three kinase 1； MAP/ERK kinase kinase 4； MAPK/ERK kinase kinase 4； MEK kinase 4； SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of； dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)； predicted protein of HQ0412； 丝裂原活化蛋白激酶激酶激酶4；
背景信息：
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6
