靶标：
AFF1
产品别名：
AF4； FEL； MLLT2； PBM1； AFF1； ALF transcription elongation factor 1； ALF transcription elongation factor 1； AF4/FMR2 family member 1； ALL1-fused gene from chromosome 4 protein； KMT2A/AFF1 fusion protein； myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2； pre-B-cell monocytic leukemia partner 1； proto-oncogene AF4； AF4/FMR2家族成员1(AFF1)； 原癌基因AF4蛋白；
背景信息：
This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in mu
