靶标：
MOV10
产品别名：
fSAP113； gb110； MOV10； Mov10 RISC complex RNA helicase； Mov10 RISC complex RNA helicase； helicase MOV-10； Mov10, Moloney leukemia virus 10, homolog； armitage homolog； functional spliceosome-associated protein 113； moloney leukemia virus 10 protein； putative helicase MOV-10； 莫洛尼白血病病毒蛋白10；
背景信息：
Putative helicase MOV-10 is an enzyme that in humans is encoded by the MOV10 gene.MOV10, also named as KIAA1631, belongs to the DNA2/NAM7 helicase family and SDE3 subfamily. It is required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). HumanMOV10may regulate a wide range of RNA viruses and could also control the retrotransposition of endogenous retroelements in mammals. MOV10 has a broad antiretroviral activity that can target a wide range of retroviruses, and it could be actively involved in host defense against retroviral infection.MOV10 can potently inhibit HIV-1 replication at multiple stages. It is involved in the progression of telomerase-catalyzing reaction via the interaction of telomerase protein and telomere DNA.
