靶标:
NACA
产品别名:
HSD48; NAC-alpha; NACA1; skNAC; NACA; nascent polypeptide associated complex subunit alpha; nascent polypeptide associated complex subunit alpha; nascent polypeptide-associated complex subunit alpha; alpha-NAC, muscle-specific form; nascent-polypeptide-associated complex alpha polypeptide; NACA1蛋白; 初生多肽相关复合物亚单位α,肌肉特异型蛋白;
背景信息:
This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes. [provided by RefSeq, Feb 2016],