靶标：
PDGFB
产品别名：
IBGC5； PDGF-2； PDGF2； SIS； SSV； c-sis； PDGFB； platelet derived growth factor subunit B； platelet derived growth factor subunit B； platelet-derived growth factor subunit B； PDGF subunit B； PDGF, B chain； becaplermin； epididymis secretory sperm binding protein； platelet-derived growth factor 2； platelet-derived growth factor B chain； platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)； platelet-derived growth factor, beta polypeptide (oncogene SIS)； proto-oncogene c-Sis； 血小板衍生生长因子B(PDGFB)；
背景信息：
platelet derived growth factor subunit B(PDGFB) Homo sapiens This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],
