靶标：
PFKFB1
产品别名：
F6PK； HL2K； PFRX； PFKFB1； 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1； 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1； 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1； 6PF-2-K/Fru-2,6-P2ASE liver isozyme； 6PF-2-K/Fru-2,6-P2ase 1； PFK/FBPase 1； fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase； 果糖-2,6-二磷酸酶1/磷酸果糖激酶2；
背景信息：
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012],
