靶标：
PIK3C2B
产品别名：
C2-PI3K； PIK3C2B； phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta； phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta； phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta； PI3K-C2-beta； PI3K-C2beta； PTDINS-3-kinase C2 beta； phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide； phosphoinositide 3-kinase-C2-beta； phosphoinositide-3-kinase, class 2, beta polypeptide； ptdIns-3-kinase C2 subunit beta； 磷酸肌醇-3-激酶2β肽(PIK3C2b)；
背景信息：
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008],
