靶标：
PKD1
产品别名：
PBP； PC1； Pc-1； TRPP1； PKD1； polycystin 1, transient receptor potential channel interacting； polycystin 1, transient receptor potential channel interacting； polycystin-1； autosomal dominant polycystic kidney disease 1 protein； polycystic kidney disease 1 (autosomal dominant)； polycystic kidney disease-associated protein； transient receptor potential cation channel, subfamily P, member 1； 多囊肾蛋白1；
背景信息：
Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.
