靶标:
SERPINF2
产品别名:
A2AP; AAP; ALPHA-2-PI; API; PLI; alpha2AP; SERPINF2; serpin family F member 2; serpin family F member 2; alpha-2-antiplasmin; alpha-2-AP; alpha-2-plasmin inhibitor; plasmin inhibitor; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; serpin F2; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; α2纤溶酶色素上皮衍生因子;
背景信息:
This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],