靶标：
PLXNB1
产品别名：
PLEXIN-B1； PLXN5； SEP； PLXNB1； plexin B1； plexin B1； plexin-B1； plexin 5； semaphorin receptor SEP； 丛状蛋白B1(PLXNB1)； 神经丛蛋白B1；
背景信息：
disease:Overexpressed and constitutively tyrosine phosphorylated in colon, liver, pancreas and gastric carcinoma cell lines. Overexpression increases MET activation and promotes invasive growth.,function:Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.,PTM:Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.,PTM:Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.,similarity:Belongs to the plexin family.,similarity:Contains 1 Sema domain.,similarity:Contains 3 IPT/TIG domains.,subunit:Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Binds PLXNA1 (By similarity). Binds ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RND1, NRP1 and NRP2.,tissue specificity:Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver.,
宿主：Rbt
类型：Pab
同种型:IgG
应用：WB
纯化方式：亲和纯化
偶联物：Unconjugated
性状：液体
存储溶液：参阅说明书
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user
储存：经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
