靶标：
POLD2
产品别名：
POLD2； DNA polymerase delta 2, accessory subunit； DNA polymerase delta 2, accessory subunit； DNA polymerase delta subunit 2； DAN polymerase delta 2, accessory subunit； DNA polymerase delta subunit p50； Pol delta B subunit (p50)； polymerase (DNA directed), delta 2, accessory subunit； polymerase (DNA directed), delta 2, regulatory subunit 50kDa； polymerase (DNA) delta 2, accessory subunit； DNA聚合酶δ； DNA聚合酶δ2/DNA polδ2；
背景信息：
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5.
