靶标:
PPP1R3C
产品别名:
PPP1R5; PTG; PPP1R3C; protein phosphatase 1 regulatory subunit 3C; protein phosphatase 1 regulatory subunit 3C; protein phosphatase 1 regulatory subunit 3C; PP1 subunit R5; Phosphatase 1, regulatory inhibitor subunit 5; protein phosphatase 1 regulatory subunit 5; protein phosphatase 1, regulatory (inhibitor) subunit 3C; protein targeting to glycogen; 蛋白磷酸酶1调节亚基3C;
背景信息:
This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. [provided by RefSeq, Sep 2016],