靶标:
HTRA1
产品别名:
ARMD7; CADASIL2; CARASIL; HtrA; L56; ORF480; PRSS11; HTRA1; HtrA serine peptidase 1; HtrA serine peptidase 1; serine protease HTRA1; IGFBP5-protease; high-temperature requirement A serine peptidase 1; protease, serine, 11 (IGF binding); 丝氨酸肽酶; 丝氨酸蛋白酶11; 高温需求因子A1(HTRA1);
背景信息:
This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008],