靶标:
PSMC6
产品别名:
RPT5; SUG2; p42; PSMC6; proteasome 26S subunit, ATPase 6; proteasome 26S subunit, ATPase 6; 26S proteasome regulatory subunit 10B; 26S proteasome AAA-ATPase subunit RPT4; proteasome (prosome, macropain) 26S subunit, ATPase, 6; proteasome subunit p42; ATP酶蛋白酶体26S亚基6(PSMC6); 蛋白酶体PRS10B;
背景信息:
proteasome 26S subunit, ATPase 6(PSMC6) Homo sapiens The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chrom