靶标：
PTPRN
产品别名：
IA-2； IA-2/PTP； IA2； ICA512； R-PTP-N； PTPRN； protein tyrosine phosphatase receptor type N； protein tyrosine phosphatase receptor type N； receptor-type tyrosine-protein phosphatase-like N； ICA 512； PTP IA-2； insulinoma-associated tyrosine-phosphatase-like protein； islet cell antigen 2； islet cell antigen 512； islet cell autoantigen 3； protein tyrosine phosphatase-like N； 蛋白酪氨酸磷酸酶受体N(PTPRN)； 蛋白酪氨酸磷酸酶样N前体蛋白；
背景信息：
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.
